Agreed about homing, although if you manually home, you can get your machine’s absolute zero pretty reliably in the same spot in order to maximize the workable area (i.e., the soft limits).
I could maybe see squeezing a corner alignment jig onto a QCW/rolling-folding and having something set up to give you a gnat’s butt accurate/repeatable workplace zero that is therefore inside the soft limit area (based on the above repeatable/accurate absolute zero).
As you (and @Aiph5u) mentioned, for a smaller project well within the soft limit area defined by the absolute x,y zero, it would be enough to just (re-) define the workpiece zero when the workpiece is re-mounted, or alternatively continue on using the offsets mentioned in Aiph5u’s “Resetting after a power…” post.