Not sure exactly, could be one or more of a few things including loose bit, lost steps with the Z-axis, or the material shifted on the bed.
Only use a V-bit for the edges of pockets, not for the inside (field) removal. I noticed your stepover for the V-bit was 2% which I imagine not only took forever to cut, but the sharp point of the V-bit is not designed for smooth, flat, surface finishing. It’s more of a form or shaping tool. I suggest switching to a V-Carve toolpath and use either a 1/4" or 1/8" flat end mill for a clearance tool. Then let the V-Bit do the edges where it works the best.
When using end mills, if I want as smooth surface as possible (i.e. less sanding), I will set the stepover for the bit to between 8 and 10 percent. Going over 10 may not be enough (sometimes it is), and I have seen diminishing returns using less than 8 or 9 percent versus the amount of time required for the carving itself.
Regarding speeds and feeds, its not easy to recommend anything specific. However, IMHO, 150 in/m and 22k RPM is somewhat high for a V-bit. With plastic (acrylic) you can’t go too fast or you will heat up and melt the material and possibly clog the flutes with this melted material. And, without getting into unnecessarily complicated chipload math, IN GENERAL the more flutes you add to the equation, the slower your bit needs to rotate and feed (relative and compared to the same size bit with less flutes) so as not to clog the flutes with material that doesn’t have time to be evacuated. Again, this is a very general statement and can change depending on material and the machine your using. Just to note, they make single-flute O-bit end mills just for plastics and foam.
So, in summary, I’ll throw out these numbers as a STARTING point if it was me doing the cutting and using a V-Carve toolpath. Also, make sure to double-check the bit is secure in the router and won’t slip.
1/4" 3 flute end mill for a clearance tool. 3 flutes is what I think is most common in use
80 in/m feed
40 in/m plunge
18k RPM
10% stepover
60 degree V-bit
40 in/m feed
20 in/m plunge
16k RPM
25% stepover (since only used for edges of pocket)
If the edges of the pocket are angled too much or the corners are not sharp enough, then switch to a 30 degree V-bit keeping same speeds.