Hey Patrick,
if you don’t reassign the axes, you change nothing in your CAM software. You just have to remember that when mounting the machine vertically to the wall in the orientation recommended by the manufacturer, the corner that seems to be on the lower left in fact remained the left rear corner of the machine, and machine home (0,0) is on the lower right.
If you have a machine with different X and Y size like 1220 × 816 mm Journeyman, and if you reassign the axes by 90° in order to have home on lower left when looked at the vertical machine, so that you now have a 816 × 1220 mm machine, then you will have to edit your CAM software’s and postprocessor’s machine limits to reflect the correct sizes of X and Y axes.
You may be interested in this.
Welcome to the forum!